Endocrine Abstracts

Background: There is concern that adolescents with childhood-onset GHD (COGHD) and persistent GH deficiency may be exposed to multiple metabolic risks after GH treatment withdrawal at the attainment of final height (FH).Aim: Aim of our study is to retrospectively compare growth response and metabolic profile in isolated idiopathic COGHD adolescents with permanent GH deficiency in comparison to GHD subjects who normalized their GH response at transition p...

Background: Several studies have investigated the effects of GH replacement therapy (GHRT) on thyroid function in children with GH deficiency (GHD) leading to contrasting results. Indeed, GHRT has been reported to affect the peripheral metabolism of thyroid hormones, to alter TSH secretion by pituitary and to unmask secondary hypothyroidism.Objective: To evaluate long-term effects of GHRT on thyroid function in a large cohort of GHD children.<p class...

Introduction: Subclinical hypothyroidism (SH) is characterized by serum TSH levels above the upper limit of the reference range, in the presence of normal serum concentrations of total T4 and free T4. Associ-ation between SH in childhood and adverse neurocognitive outcomes remains controversial.Objective: To evaluate the intellectual outcome of children with SH before and after 2 years of treatment with levothyroxine (L-T4).Methods...

Background: P450 Oxidoreductase (POR) Deficiency(PORD) represents the most complex form of congenital adrenal hyperplasia. It usuallycauses genital ambiguity in both sexes, and eventually peculiar skeletal malformations resembling Antley-Bixler syndrome. Co-occurrence of POR deficiency and Argininosuccinatelyase Deficiency (ALD)in the samepatient born to non-consanguineous parents has never been reported.Case report: A male patient was born at term to no...